Louis Meyer, with mechanic Lawson Harris of Indianapolis, won his second 500 and set a speed record of 104.162 mph, slightly faster than Fred Frame the year before. Second place went to Wilbur Shaw.

It was a tough year as five men died in accidents at the track. Driver Bill Denver (aka Bill Orem) and his mechanic, Hugh "Bob" Hurst, died during qualifications. During the race, drivers Mark Billman and Lester Spangler died in separate accidents. Spangler's mechanic, G.L. "Monk" Jordan, was also killed. Hurst and Billman were Indianapolis residents and Jordan was from Lafayette.

Chet Gardner's crew introduced an innovative bit of technology -- a two-way radio in his car, enabling mechanic Herschell McKee to communicate with the pit crew. They came in fourth.